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1.

Loss of epigenetic information as a cause of mammalian aging.

Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T; Amorim, João A; Bonkowski, Michael S; Apostolides, John K; Salfati, Elias L; Blanchette, Marco; Munding, Elizabeth M; Bhakta, Mital; Chew, Yap Ching; Guo, Wei; Yang, Xiaojing; Maybury-Lewis, Sun; Tian, Xiao; Ross, Jaime M; Coppotelli, Giuseppe; Meer, Margarita V; Rogers-Hammond, Ryan; Vera, Daniel L; Lu, Yuancheng Ryan; Pippin, Jeffrey W; Creswell, Michael L; Dou, Zhixun; Xu, Caiyue; Mitchell, Sarah J; Das, Abhirup; O'Connell, Brendan L; Thakur, Sachin; Kane, Alice E; Su, Qiao; Mohri, Yasuaki; Nishimura, Emi K; Schaevitz, Laura; Garg, Neha; Balta, Ana-Maria; Rego, Meghan A; Gregory-Ksander, Meredith; Jakobs, Tatjana C; Zhong, Lei; Wakimoto, Hiroko; El Andari, Jihad; Grimm, Dirk; Mostoslavsky, Raul; Wagers, Amy J; Tsubota, Kazuo; Bonasera, Stephen J; Palmeira, Carlos M; Seidman, Jonathan G; Seidman, Christine E.

Cell; 186(2): 305-326.e27, 2023 01 19.

Artículo en Inglés | MEDLINE | ID: mdl-36638792

2.

Loss of epigenetic information as a cause of mammalian aging.

Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T; Amorim, João A; Bonkowski, Michael S; Apostolides, John K; Salfati, Elias L; Blanchette, Marco; Munding, Elizabeth M; Bhakta, Mital; Chew, Yap Ching; Guo, Wei; Yang, Xiaojing; Maybury-Lewis, Sun; Tian, Xiao; Ross, Jaime M; Coppotelli, Giuseppe; Meer, Margarita V; Rogers-Hammond, Ryan; Vera, Daniel L; Lu, Yuancheng Ryan; Pippin, Jeffrey W; Creswell, Michael L; Dou, Zhixun; Xu, Caiyue; Mitchell, Sarah J; Das, Abhirup; O'Connell, Brendan L; Thakur, Sachin; Kane, Alice E; Su, Qiao; Mohri, Yasuaki; Nishimura, Emi K; Schaevitz, Laura; Garg, Neha; Balta, Ana-Maria; Rego, Meghan A; Gregory-Ksander, Meredith; Jakobs, Tatjana C; Zhong, Lei; Wakimoto, Hiroko; El Andari, Jihad; Grimm, Dirk; Mostoslavsky, Raul; Wagers, Amy J; Tsubota, Kazuo; Bonasera, Stephen J; Palmeira, Carlos M; Seidman, Jonathan G; Seidman, Christine E.

Cell; 187(5): 1312-1313, 2024 Feb 29.

Artículo en Inglés | MEDLINE | ID: mdl-38428398

3.

Reprogramming Enhancers to Drive Metastasis.

Mostoslavsky, Raul; Bardeesy, Nabeel.

Cell; 170(5): 823-825, 2017 08 24.

Artículo en Inglés | MEDLINE | ID: mdl-28841414

4.

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Kugel, Sita; Sebastián, Carlos; Fitamant, Julien; Ross, Kenneth N; Saha, Supriya K; Jain, Esha; Gladden, Adrianne; Arora, Kshitij S; Kato, Yasutaka; Rivera, Miguel N; Ramaswamy, Sridhar; Sadreyev, Ruslan I; Goren, Alon; Deshpande, Vikram; Bardeesy, Nabeel; Mostoslavsky, Raul.

Cell; 165(6): 1401-1415, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27180906

5.

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Masri, Selma; Rigor, Paul; Cervantes, Marlene; Ceglia, Nicholas; Sebastian, Carlos; Xiao, Cuiying; Roqueta-Rivera, Manuel; Deng, Chuxia; Osborne, Timothy F; Mostoslavsky, Raul; Baldi, Pierre; Sassone-Corsi, Paolo.

Cell; 158(3): 659-72, 2014 Jul 31.

Artículo en Inglés | MEDLINE | ID: mdl-25083875

6.

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer.

Guo, Hongshan; Golczer, Gabriel; Wittner, Ben S; Langenbucher, Adam; Zachariah, Marcus; Dubash, Taronish D; Hong, Xin; Comaills, Valentine; Burr, Risa; Ebright, Richard Y; Horwitz, Elad; Vuille, Joanna A; Hajizadeh, Soroush; Wiley, Devon F; Reeves, Brittany A; Zhang, Jia-Min; Niederhoffer, Kira L; Lu, Chenyue; Wesley, Benjamin; Ho, Uyen; Nieman, Linda T; Toner, Mehmet; Vasudevan, Shobha; Zou, Lee; Mostoslavsky, Raul; Maheswaran, Shyamala; Lawrence, Michael S; Haber, Daniel A.

Mol Cell; 81(19): 4041-4058.e15, 2021 10 07.

Artículo en Inglés | MEDLINE | ID: mdl-34624217

7.

Resveratrol: Friend or Foe?

Clarke, Thomas L; Mostoslavsky, Raul.

Mol Cell; 79(5): 705-707, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32888435

8.

SIRT6, a Mammalian Deacylase with Multitasking Abilities.

Chang, Andrew R; Ferrer, Christina M; Mostoslavsky, Raul.

Physiol Rev; 100(1): 145-169, 2020 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-31437090

9.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián, Carlos; Zwaans, Bernadette M M; Silberman, Dafne M; Gymrek, Melissa; Goren, Alon; Zhong, Lei; Ram, Oren; Truelove, Jessica; Guimaraes, Alexander R; Toiber, Debra; Cosentino, Claudia; Greenson, Joel K; MacDonald, Alasdair I; McGlynn, Liane; Maxwell, Fraser; Edwards, Joanne; Giacosa, Sofia; Guccione, Ernesto; Weissleder, Ralph; Bernstein, Bradley E; Regev, Aviv; Shiels, Paul G; Lombard, David B; Mostoslavsky, Raul.

Cell; 151(6): 1185-99, 2012 Dec 07.

Artículo en Inglés | MEDLINE | ID: mdl-23217706

10.

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Etchegaray, Jean-Pierre; Zhong, Lei; Li, Catherine; Henriques, Telmo; Ablondi, Eileen; Nakadai, Tomoyoshi; Van Rechem, Capucine; Ferrer, Christina; Ross, Kenneth N; Choi, Jee-Eun; Samarakkody, Ann; Ji, Fei; Chang, Andrew; Sadreyev, Ruslan I; Ramaswamy, Sridhar; Nechaev, Sergei; Whetstine, Johnathan R; Roeder, Robert G; Adelman, Karen; Goren, Alon; Mostoslavsky, Raul.

Mol Cell; 75(4): 683-699.e7, 2019 08 22.

Artículo en Inglés | MEDLINE | ID: mdl-31399344

11.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

Jung, Su Myung; Hung, Chien-Min; Hildebrand, Samuel R; Sanchez-Gurmaches, Joan; Martinez-Pastor, Barbara; Gengatharan, Jivani M; Wallace, Martina; Mukhopadhyay, Dimpi; Martinez Calejman, Camila; Luciano, Amelia K; Hsiao, Wen-Yu; Tang, Yuefeng; Li, Huawei; Daniels, Danette L; Mostoslavsky, Raul; Metallo, Christian M; Guertin, David A.

Mol Cell; 75(4): 807-822.e8, 2019 08 22.

Artículo en Inglés | MEDLINE | ID: mdl-31442424

12.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer, Christina M; Alders, Marielle; Postma, Alex V; Park, Seonmi; Klein, Mark A; Cetinbas, Murat; Pajkrt, Eva; Glas, Astrid; van Koningsbruggen, Silvana; Christoffels, Vincent M; Mannens, Marcel M A M; Knegt, Lia; Etchegaray, Jean-Pierre; Sadreyev, Ruslan I; Denu, John M; Mostoslavsky, Gustavo; van Maarle, Merel C; Mostoslavsky, Raul.

Genes Dev; 32(5-6): 373-388, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29555651

13.

SIRT3 in calorie restriction: can you hear me now?

Sebastian, Carlos; Mostoslavsky, Raul.

Cell; 143(5): 667-8, 2010 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-21111225

14.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong, Lei; D'Urso, Agustina; Toiber, Debra; Sebastian, Carlos; Henry, Ryan E; Vadysirisack, Douangsone D; Guimaraes, Alexander; Marinelli, Brett; Wikstrom, Jakob D; Nir, Tomer; Clish, Clary B; Vaitheesvaran, Bhavapriya; Iliopoulos, Othon; Kurland, Irwin; Dor, Yuval; Weissleder, Ralph; Shirihai, Orian S; Ellisen, Leif W; Espinosa, Joaquin M; Mostoslavsky, Raul.

Cell; 140(2): 280-93, 2010 Jan 22.

Artículo en Inglés | MEDLINE | ID: mdl-20141841

15.

Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair.

Linder, Samantha J; Mostoslavsky, Raul.

Mol Cell; 67(2): 165-167, 2017 Jul 20.

Artículo en Inglés | MEDLINE | ID: mdl-28732204

16.

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

Etchegaray, Jean-Pierre; Mostoslavsky, Raul.

Mol Cell; 62(5): 695-711, 2016 06 02.

Artículo en Inglés | MEDLINE | ID: mdl-27259202

17.

SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

Asher, Gad; Gatfield, David; Stratmann, Markus; Reinke, Hans; Dibner, Charna; Kreppel, Florian; Mostoslavsky, Raul; Alt, Frederick W; Schibler, Ueli.

Cell; 134(2): 317-28, 2008 Jul 25.

Artículo en Inglés | MEDLINE | ID: mdl-18662546

18.

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer, Philipp; Michan, Shaday; McVay, Michael; Mostoslavsky, Raul; Vann, James; Park, Sang-Kyu; Hartlerode, Andrea; Stegmuller, Judith; Hafner, Angela; Loerch, Patrick; Wright, Sarah M; Mills, Kevin D; Bonni, Azad; Yankner, Bruce A; Scully, Ralph; Prolla, Tomas A; Alt, Frederick W; Sinclair, David A.

Cell; 135(5): 907-18, 2008 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-19041753

19.

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Toiber, Debra; Erdel, Fabian; Bouazoune, Karim; Silberman, Dafne M; Zhong, Lei; Mulligan, Peter; Sebastian, Carlos; Cosentino, Claudia; Martinez-Pastor, Barbara; Giacosa, Sofia; D'Urso, Agustina; Näär, Anders M; Kingston, Robert; Rippe, Karsten; Mostoslavsky, Raul.

Mol Cell; 51(4): 454-68, 2013 Aug 22.

Artículo en Inglés | MEDLINE | ID: mdl-23911928

20.

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.

Arsiwala, Tasneem; Pahla, Jürgen; van Tits, Lambertus J; Bisceglie, Lavinia; Gaul, Daniel S; Costantino, Sarah; Miranda, Melroy X; Nussbaum, Kathrin; Stivala, Simona; Blyszczuk, Przemyslaw; Weber, Julien; Tailleux, Anne; Stein, Sokrates; Paneni, Francesco; Beer, Jürg H; Greter, Melanie; Becher, Burkhard; Mostoslavsky, Raul; Eriksson, Urs; Staels, Bart; Auwerx, Johan; Hottiger, Michael O; Lüscher, Thomas F; Matter, Christian M.

J Mol Cell Cardiol; 139: 24-32, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31972266

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Loss of epigenetic information as a cause of mammalian aging.

Loss of epigenetic information as a cause of mammalian aging.

Reprogramming Enhancers to Drive Metastasis.

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer.

Resveratrol: Friend or Foe?

SIRT6, a Mammalian Deacylase with Multitasking Abilities.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

SIRT3 in calorie restriction: can you hear me now?

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair.

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.